Thursday, May 27, 2010

Medco's Pharmacogenomic Future

The 2010 Drug Trend Report from Medco Health Solutions (NYSE:MHS) is now available. Like Express Scripts’ drug trend report, I recommend you download this valuable free resource.

Medco’s report provides loads of data from its top 201 clients (65% of total spend). But the most interesting part of the report for me deals with Medco’s future strategy.

Pharmacogenomics—using genetic variations to improve drug response—is the foundation of Medco’s Making Medicine Smarter™ message. I think it provides a powerful platform for the company in a post-2014 world with few generic launches. If this revolution turns out to be real, then Medco will win big in the personalized medicine future.


A few nuggets from the report:
  • Specialty trend was 14.7%, or more than 8X the 1.8% trend of traditional drugs. For comparison, Medco’s specialty trend was 15.8% in 2008.
  • Specialty trend was driven by higher “unit cost,” which reflects both price increases and therapeutic mix in Medco’s lexicon. Utilization refers to “the quantity of drugs obtained by plan members.” For specialty drugs, utilization crept up by only 2.6% while unit costs jumped 12.1%.
Note that Medco presents it data in a different way from Express Scripts, so it’s impossible to make comparisons across trend reports.

Medco made an effort to slice the data to dig out newsworthy nuggets. For example:
  • Drug trend for children (under age 19) exceeded all other age groups. However, total spending remains concentrated in older patients. Net plan costs in 2009 for people over 65 was $1,833 versus $233 for members under 19. (See page 30.)
  • They correlated sleep deprivation and drug utilization (page 32). OK, whatever. I’m skeptical of this finding, but then again I live in the hard-charging sleep-deprived Northeast instead of the apparently well-rested West Coast.

You have to wait until page 86 for the most fascinating part of the report—a primer on personalized medicine, defined by Medco as follows:
“Personalized medicine, or the practice of using diagnostic tests to detect and tailor treatments based on unique individual genetic variations, holds the promise of making medical care more precise and effective.”
As it happens, I was at a fascinating talk by Robert Epstein, the Chief Medical Officer at Medco, in Boston on Wednesday. The possibilities for more effective care (and better management of trend) are truly astounding. BTW, Dr. Epstein is a very engaging and informative speaker, so try to hear him if you get the chance.

For example, Medco is conducting a series of comparative effectiveness clinical trials under a concept they call Genetics for Generics™. (Hmmm, another trademarked phrase.) As I understand the program, Medco intends to use biomarkers to optimize drug treatment when:
  • A generic competes with a brand name drug
  • Multiple generic drugs could be used for the same indication
  • Treatment regimen of a generic could be optimized
I wrote about Medco’s GFG comparative effectiveness trial of Effient vs. Plavix in Medco Takes on Eli Lilly. I also suggest Medco Makes Push for Genetic Test from last week's Wall Street Journal.

Medco is investing heavily in creating a future for the PBM industry. Will it work?


Check out the latest Health Wonk Review for a round-up of news analysis from the blogosphere.

P.S. The image above comes from the awesome t-shirt collection at Mental Floss.

1 comment:

  1. interesting post. There are many small companies filling the personalized/phamacogenomic space at the moment. We started up a company that we have high hopes will be integral to the biomarker discovery and implementation side of the personalized medicine equation. The novel technology ( uses the dynamics of protein interaction networks to not only discriminate patients for particular therapeutic regimes but also suggests new targets for for patients without a tailored therapy.


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