Friday, June 15, 2018

Specialty Pharmacy Management of Migraine Patients

Today’s guest post comes from Lily Duong, Chief Clinical Officer at Therigy.

Lily discusses new migraine treatments that treat or prevent chronic and episodic migraine headaches. She highlights how these therapies will challenge specialty pharmacies.

Therigy has developed a migraine therapy management solution to assist specialty pharmacies with patient management. To learn more, schedule a live demo of the TherigySTM™ migraine care plan.

Read on for Lily’s insights.

Specialty Pharmacy Management of Migraine Patients 
By Lily Duong, PharmD, RPh, Chief Clinical Officer, Therigy

It is estimated that migraines are the third most prevalent illness in the world, affecting 39 million people in the U.S. and one billion globally. This debilitating condition is known to impact a patient’s quality of life, with a reported 90 percent of sufferers being unable to function normally while experiencing symptoms. Compared to patients with episodic migraine, those with chronic migraines have worse socioeconomic status, reduced health-related quality of life, increased headache-related burden, and greater psychiatric and medical comorbidities.

To better help these patients and the specialists who treat them, Therigy is announcing the addition of a dedicated migraine care plan within TherigySTM™, a patient-centered therapy management solution. This new disease state care plan will better assist specialty pharmacies in clinically managing patients who are prescribed this new drug therapy to treat or prevent chronic and episodic migraine headaches.

With the recent introduction of Aimovig™ (erenumab-aooe) to the market (Amgen and Novartis drug) and the expected release of other new biologic migraine treatments in the coming months, the care plan comes at just the right time for specialty pharmacies to integrate comprehensive assessments, evidence-based therapy management, reporting metrics and outcomes to provide the best possible care.


Last month, Amgen received FDA approval for Aimovig, the first approved treatment developed to prevent migraines by blocking the CGRP-R (calcitonin gene-related peptide receptor).

Three other anti-CGRP treatments are on the horizon from pharmaceutical leaders Teva Pharmaceuticals, Eli Lilly, and Alder Biopharmaceuticals. Teva is expected to launch their migraine drug mid-September after experiencing an initial delay. Eli Lilly and Alder are expected to file for FDA approval later in 2018.

Each of these therapies focus on CGRP and its receptor in the brain. CGRP is a potent dilator of cerebral and dural vessels, and it is involved in meningeal dural vasodilation. Cranial CGRP levels are elevated in patients with migraines, and an infusion of CGRP can trigger a migraine attack. These therapies work by utilizing one of four antibodies: erenumab, which targets the CGRP receptor, as well as eptinezumab, fremanezumab, and galcanezumab, which target CGRP itself.

Each of these upcoming therapies has shown to decrease migraine frequency by one to two days each month, giving migraine sufferers new hope for the ability to manage their condition and live their fullest lives.


The new care plan will complement existing care plans within the TherigySTM platform through the TherigyAssure module, software as a service (SaaS) solution, providing specialty pharmacies with a robust library of clinical assessments, protocols, activities, surveys, and reporting capabilities to better manage patients who are undergoing treatment for chronic or episodic migraines.

Clinical assessments and care plans help specialty pharmacies more holistically manage patients, leading to successful therapy outcomes. Therigy’s new migraine module will provide clinical resources for clinicians to perform proper assessments, develop individualized care plans, and provide required interventions and follow up evaluation to achieve successful outcomes.

To learn more, schedule a live demo of the TherigySTM™ migraine care plan.

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